USA Up All Night began on January 7, 1989, with Gilbert Gottfried as the host. Later, Rhonda Shear was added as the Friday night host. The series involved the hosts introducing usually B-movies, and skits before and after commercial breaks, that would play for those who were up all night over the weekend.

Taking this stroll down late-night television with Milo and Jamie is Katie from the Retromade Podcast, as the three discuss the history of the show, along with their memories of it.